E. Bottini, Brief communication: Association between cytosolic low molecular weight phosphotyrosine-phosphatase and malaria - A possible mechanism, AM J P ANTH, 108(2), 1999, pp. 241-244
Cytosolic low molecular weight phosphotyrosine-phosphatase shows dephosphor
ylating activity of the band 3 protein. Increased phosphorylation of this p
rotein increases membrane rigidity and resistance to invasion of red blood
cells by malarial parasites. This observation may explain the negative asso
ciation previously reported by our group between the high activity *C allel
e of cytosolic low molecular weight phosphotyrosine-phosphatase and past ma
larial morbidity. (C) 1999 Wiley-Liss, Inc.