Molecular sequence analysis is providing new insights into the study of met
azoan relationships, The use of ribosomal RNA sequences is revising many of
the metazoan phylogenies that have been established traditionally with ana
tomical and embryological data. Four new findings that seem to be well supp
orted by molecular data, both from the authors' laboratories and from other
s, are described and discussed. First, the arthropods are members of a deep
primary clade within the protostomes and are not the sister taxa of either
the annelids or the mollusks, Second, the lophophorate animals are clearly
protostomes and are contained within a lophotrochozoan superclade includin
g the mollusks, annelids, and many other phyla. Third, the arthropods toget
her with all other molting animals comprise a second monophyletic superclad
e within the protostomes, the ecdysozoa, Fourth, the platyhelminthes are co
ntained within the lophotrochozoan superclade.