PHOTO-SENSITIZED FORMATION OF THE CIS-(5R, 6R) DIASTEREOMER OF ,6-DIHYDROXY-5,6-DIHYDRO-5-METHYL-2'-DEOXYCYTIDINE

Authors
BIENVENU C LEBRUN C CADET J
Citation
C. Bienvenu et al., PHOTO-SENSITIZED FORMATION OF THE CIS-(5R, 6R) DIASTEREOMER OF ,6-DIHYDROXY-5,6-DIHYDRO-5-METHYL-2'-DEOXYCYTIDINE, Journal de chimie physique et de physico-chimie biologique, 94(2), 1997, pp. 300-305
Citations number
6
Categorie Soggetti
Biology,"Chemistry Physical
Journal title
Journal de chimie physique et de physico-chimie biologique → ACNP
Volume
94
Issue
2
Year of publication
1997
Pages
300 - 305
Database
ISI
SICI code
Abstract
The ,6-dihydroxy-5,6-dihydro-5-methyl-2'-deoxycytidine is an oxidation product formed by hydroxyl radical ((OH)-O-.). The same product has b een obtained by menadione photosensitization of 5-methyl-2'-deoxycytid ine (m(5)dCyd). O-18 labeling experiments led us to suggest a mechanis m for the photosensitized formation of ,6-dihydroxy-5,6-dihydro-5-meth yl-2'-deoxycytidine involving initial generation of the m(5)dCyd radic al cation.