Epstein-Barr virus in Hodgkin's disease

Epstein-Barr virus (EBV), a B-lymphotropic herpesvirus wide-spread in human populations, is carried by most individuals as an asymptomatic lifelong in fection. Much progress has been made in our understanding of virus infectio n/persistence, and in the Pole of the cytotoxic T lymphocyte response in co ntrol of that infection. This same virus is linked to several malignancies, including endemic Burkitt's lymphoma, post-transplant lymphoproliferative disease and to many cases of Hodgkin's disease (HD). Recent evidence showin g that HD, like the other EBV-associated lymphomas, is of B-cell origin sug gests that the pathogenesis of these malignancies may share more common gro und than previously thought. The biology and cytotoxic T-cell control of pr imary and persistent EBV infection, and the links between EBV and all three lymphomas are reviewed. The expression of viral antigens in EBV-positive H D raises the possibility of developing tumour immunotherapy: using relevant components of the EBV-specific T-cell response; progress to date, and futu re prospects for immune control of EBV-positive HD are discussed.