Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa

Citation
N. Masuda et al., Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa, ANTIM AG CH, 43(2), 1999, pp. 400-402
Citations number
26
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
2
Year of publication
1999
Pages
400 - 402
Database
ISI
SICI code
0066-4804(199902)43:2<400:IBCBAT>2.0.ZU;2-T
Abstract
We investigated the role of chromosomal beta-lactamase and the MexAB-OprM e fflux system in intrinsic resistance to beta-lactams in Pseudomonas aerugin osa. Determination of the susceptibilities of a series of isogenic mutants with impaired production of the beta-lactamase and the efflux system to 16 beta-lactams including penicillins, cephems, oxacephems, carbapenems, and a monobactam demonstrated that the intrinsic resistance of P. aeruginosa to most of the beta-lactams is due to the interplay of both factors.