Citation
T. Mine et al., Expression in Escherichia coli of a new multidrug efflux pump, MexXY, fromPseudomonas aeruginosa, ANTIM AG CH, 43(2), 1999, pp. 415-417
Citations number
26
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804
→ ACNP
Volume
43
Issue
2
Year of publication
1999
Pages
415 - 417
Database
ISI
SICI code
0066-4804(199902)43:2<415:EIECOA>2.0.ZU;2-5
Abstract
Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating mult
idrug resistance were cloned from the chromosome of Pseudomonas aeruginosa.
Elevated ethidium extrusion was observed with Escherichia coli cells harbo
ring the plasmid carrying mexXY. This MexXY system confers higher resistanc
e to fluoroquinolones than the MexAB and MexCD systems, and E. coli TolC or
P. aeruginosa OprM is necessary for the function of the MexXY system.