Activity of a heat-induced reformulation of amphotericin B deoxycholate (Fungizone) against Leishmania donovani

Authors
Petit, C Yardley, V Gaboriau, F Bolard, J Croft, SL
Citation
C. Petit et al., Activity of a heat-induced reformulation of amphotericin B deoxycholate (Fungizone) against Leishmania donovani, ANTIM AG CH, 43(2), 1999, pp. 390-392
Citations number
28
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
2
Year of publication
1999
Pages
390 - 392
Database
ISI
SICI code
0066-4804(199902)43:2<390:AOAHRO>2.0.ZU;2-S
Abstract
The heat treatment of amphotericin B deoxycholate (Fungizone), which aas pr eviously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.