Comparative activities of clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, ofloxacin, sparfloxacin, and trovafloxacin and nonquinolones linozelid, quinupristin-dalfopristin, gentamicin, and vancomycin against clinical isolates of ciprofloxacin-resistant and -susceptible Staphylococcus aureus strains

The activities of eight fluoroquinolones and linezolid, quinupristin-dalfop ristin (Synercid), gentamicin, and vancomycin were tested against 96 ciprof loxacin-susceptible and 205 ciprofloxacin-resistant Staphylococcus aureus s trains. Overall, clinafloxacin, followed by moxifloxacin and trovafloxacin, was the most active quinolone tested. For all isolates, linezolid and quin upristin-dalfopristin showed activities that were at least comparable to va ncomycin, with no cross-resistance to any other test compound.