Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum

In a murine model of Leishmania infantum visceral leishmaniasis, metronidaz ole, ketoconazole, fluconazole, itraconazole, and terbinafine were less eff ective than antimonial agents in reducing hepatic parasite load. Ketoconazo le potentiated the effect of meglumine antimoniate reference therapy throug h its marked activity against spleen infection.