Penetration of oral fluconazole into gynecological tissues

Penetration of fluconazole into female genital tissues was examined. Flucon azole was administered orally at a dose of 150 mg to patients undergoing to tal abdominal hysterectomy 1 to 151 h prior to surgery, During surgery, blo od, uterus, ovary, and oviduct were sampled, Fluconazole concentrations in each tissue Here determined by high-performance liquid chromatography. The peak concentrations in serum reached approximately 6.1 mu g/ml 1.0 h after a drip infusion was begun. At each time after the infusion, the concentrati ons in portio vaginalis, cervix uteri, myometrium, endometrium, ovary, and oviduct were higher than those in the serum: the peaks in the tissues range d from 6.4 to 9.5 mu g/g around 1.0 h after the drip infusion was begun, Th us, the levels of penentration of fluconazole into gynecological tissues ap peared to be similar to or slightly above those in serum samples. Flucanazo le can rapidly penetrate from plasma into the female genital organs, suppor ting high efficacy of fluconazole against fungal infections in the field of gynecology.