A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997-1998 season in Tokyo

Authors
Mori, SI Nagashima, M Sasaki, Y Mori, K Tabei, Y Yoshida, Y Yamazaki, K Hirata, I Sekine, H Ito, T Suzuki, S
Citation
Si. Mori et al., A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997-1998 season in Tokyo, ARCH VIROL, 144(1), 1999, pp. 147-155
Citations number
39
Categorie Soggetti
Microbiology
Journal title
ARCHIVES OF VIROLOGY
ISSN journal
03048608 → ACNP
Volume
144
Issue
1
Year of publication
1999
Pages
147 - 155
Database
ISI
SICI code
0304-8608(1999)144:1<147:ANAASA>2.0.ZU;2-6
Abstract
We analyzed the hemagglutinin (HA) genes of influenza A viruses consisting of 6 strains isolated from cerebrospinal fluids of patients with encephalop athy and 3 isolates from throat washes of patients without central nervous system symptoms during the 1997-1998 season in Tokyo. Aligned 9 amino acid sequences showed 7 common substitutions compared with A/Wuhan/359/95 (vacci ne strain used in the season in Japan), which were allocated to three diffe rent antigenic sites on the H3 HA molecule. It is noted that a novel substi tution at the receptor-binding site (Tyr-137 to Phe) was found exclusively in the isolates from the patients with encephalopathy.