Resveratrol, a natural product present in wine, decreases tumour growth ina rat tumour model

Authors
Carbo, N Costelli, P Baccino, FM Lopez-Soriano, FJ Argiles, JM
Citation
N. Carbo et al., Resveratrol, a natural product present in wine, decreases tumour growth ina rat tumour model, BIOC BIOP R, 254(3), 1999, pp. 739-743
Citations number
26
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
254
Issue
3
Year of publication
1999
Pages
739 - 743
Database
ISI
SICI code
0006-291X(19990127)254:3<739:RANPPI>2.0.ZU;2-V
Abstract
Resveratrol administration to rats inoculated with a fast growing tumour (t he Yoshida AH-130 ascites hepatoma) caused a very significant decrease (25% ) in the tumour cell content. The effects of this diphenol were associated with an increase in the number of cells in the G(2)/M cell cycle phase. Int erestingly, flow cytometric analysis of the tumour cell population revealed the existence of an aneuploid peak (representing 28% of total), which sugg ests that resveratrol causes apoptosis in the tumour cell population result ing in a decreased cell number. (C) 1999 Academic Press.