Reduced sensitivity of HeLa cells to cis-platinum by simultaneous overexpression of copper, zinc-superoxide dismutase and catalase

Authors
Tanaka-Kagawa, T Kitahara, J Seko, Y Toyoda, H Imura, N Naganuma, A
Citation
T. Tanaka-kagawa et al., Reduced sensitivity of HeLa cells to cis-platinum by simultaneous overexpression of copper, zinc-superoxide dismutase and catalase, BIOCH PHARM, 57(5), 1999, pp. 545-548
Citations number
31
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOCHEMICAL PHARMACOLOGY
ISSN journal
00062952 → ACNP
Volume
57
Issue
5
Year of publication
1999
Pages
545 - 548
Database
ISI
SICI code
0006-2952(19990301)57:5<545:RSOHCT>2.0.ZU;2-C
Abstract
The overexpression of catalase or Cu,Zn-superoxide dismutase (Cu,Zn SOD) di d not affect the sensitivity of HeLa cells to cis-platinum. However, the cy totoxicity of cis-platinum was depressed significantly by the simultaneous overexpression of catalase and Cu,Zn-SOD. We concluded that cis-platinum ac celerated the generation of superoxide anion in the cells, and the superoxi de anion produced was converted into H2O by the cooperative roles of catala se and Cu,Zn-SOD. BIOCHEM PHARMACOL 57;5:545-548, 1999. (C) 1999 Elsevier S cience Inc.