R. Bahulekar et al., Platelet adhesion and complement activation studies on poly(N-alkyl mono and disubstituted) acrylamide derivatives, BIOMATERIAL, 20(4), 1999, pp. 357-362
Poly(N-alkyl mono and disubstituted) acrylamide derivatives were synthesize
d from poly(acryloyl chloride) by monomer analogous reaction. The polymers
were characterized by FTIR-ATR and GPC. The contact angle measurements were
performed to evaluate hydrophobic/hydrophilic characters of these polymers
. The N-alkyl substituents changed contact angle between 55 and 75 degrees.
In vitro platelet adhesion studies showed that surfaces of poly(N-alkyl su
bstituted) acrylamides are prone to adhere platelets. Platelet spreading wa
s more on poly(N-benzyl-N-ethyl acrylamide) surfaces in comparison to that
on poly(N-benzyl-N-propionic acid ethyl eater acrylamide) and poly(hi-benzy
l acrylamide) surfaces. As a result of modification of amino group with N-a
lkyl substituents, the activations of C3a and C5a complements were suppress
ed 9-20% and 5-6% of native poly(acrylamides), respectively. (C) 1999 Elsev
ier Science Ltd. All rights reserved.