Safety-catch and multiply cleavable linkers in solid-phase synthesis

This review article focuses on concepts that incorporate safety-catch and m ultiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics , and "small" organic molecules, as well as their limitations Sol particula r chemistries and reaction conditions. (C) 1999 John Wiley & Sons, Inc.