Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration

Authors
Sullivan, AM Opacka-Juffry, J Pohl, J Blunt, SB
Citation
Am. Sullivan et al., Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration, BRAIN RES, 818(1), 1999, pp. 176-179
Citations number
8
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
818
Issue
1
Year of publication
1999
Pages
176 - 179
Database
ISI
SICI code
0006-8993(19990206)818:1<176:NEOGF5>2.0.ZU;2-X
Abstract
Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway fr om 6-hydroxy-dopamine-induced da mage. Here we used amphetamine-induced rotational testing, high-performance liquid chromatography and immunocytochemistry to investigate the minimum e ffective dose of GDF5. Wt also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventric le (LV) or the striatum (or combinations of these sites). (C) 1999 Elsevier Science B.V. All rights reserved.