Blockade of K+ current and modulation of ionotropic glutamate responses indissociated cortical neurons of rat by sigma ligand

Effects of a ligands, NE-100 and SKF 10,047 were investigated in acutely di ssociated rat cortical neurons using nystatin perforated patch recording co nfiguration under voltage-clamp condition. Both NE-100 and SKF 10,047 induc ed inward currents, resulting from the blockade of tonic, outward K+ curren t. They also suppressed NMDA-induced inward current but oppositely potentia ted AMPA- and KA-induced inward currents, indicating that these a ligands d ifferently modulate the ionotropic glutamate responses.