The 1996 Veylien Henderson Award of the Society of Toxicology of Canada. Current concepts: neutrophils and the activation of carcinogens in the breast and other organs

Authors
Josephy, PD Coomber, BL
Citation
Pd. Josephy et Bl. Coomber, The 1996 Veylien Henderson Award of the Society of Toxicology of Canada. Current concepts: neutrophils and the activation of carcinogens in the breast and other organs, CAN J PHYSL, 76(7-8), 1998, pp. 693-700
Citations number
98
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
ISSN journal
00084212 → ACNP
Volume
76
Issue
7-8
Year of publication
1998
Pages
693 - 700
Database
ISI
SICI code
0008-4212(199807/08)76:7-8<693:T1VHAO>2.0.ZU;2-R
Abstract
Many chemical carcinogens target epithelial tissues, but the biological and biochemical bases of carcinogen specificity remain largely unknown. Focusi ng on the mammary gland, we discuss the concept that neutrophils metabolize carcinogens to reactive species that damage adjacent epithelial cells. Thi s mechanism may help to explain why epithelial cells are sensitive targets for chemical carcinogenesis, despite their limited bioactivation capacity.