Dietary factors and the risk of squamous cell esophageal cancer among black and white men in the United States

Objectives: To investigate dietary factors for squamous cell esophageal can cer and whether these factors may contribute to the five-fold higher incide nce of this cancer in the black versus white population of the United State s. Methods: Data from a food frequency questionnaire were analyzed for 114 whi te men and 219 black men with squamous cell esophageal cancer, and 681 whit e and 557 black male controls from three areas of the United States who par ticipated in a population-based case-control study of esophageal cancer. Results: Protective effects were associated with intake of raw fruits and v egetables (odds ratio for high versus low consumers = 0.3 in both white and black men) and use of vitamin supplements (especially vitamin C; odds rati o for high versus low consumers = 0.4 in both races), with the frequency of consumption of raw fruits and vegetables and vitamin supplements being gre ater for white than black controls. In addition, elevated risks were associ ated with high versus low intake of red meat (OR = 2.7 for blacks and 1.5 f or whites) and processed meat (OR = 1.6 for blacks and 1.7 for whites), wit h the levels of consumption being greater for black than white controls. Conclusions: In the United States, these dietary factors may contribute in part to the much higher incidence of squamous cell esophageal cancer among black compared to white men.