Invasive infections due to Clavispora lusitaniae

Three cases of Clavispora lusitaniae invasive fungal infections are reporte d. All three infections appeared in cancer patients presented with fungaemi a, one additionally with meningitis. Two of them were breakthrough - they d eveloped during therapy with conventional amphotericin B with a dose of 0.5 mg kg(-1) day(-1). All three were cured: two with intravenous fluconazol a nd one with an increasing dose (1 mg kg(-1) day(-1)) of amphotericin B. Ln one of two breakthrough cases the sensitivity of the strain to antifungals was tested against antifungal agents and showed in vitro resistance to amph otericin B (MIC 2 eta g ml(-1)). (C) 1999 Federation of European Microbiolo gical Societies. Published by Elsevier Science B.V. All rights reserved.