J. Favor et A. Neuhauser-klaus, Loss of heterozygosity at the dilute short ear (Myo5a-Bmp5) region of the mouse: mitotic recombination or double non-disjunction?, GENET RES, 72(3), 1998, pp. 199-204
The occurrence of homozygous-viable dilute-short ear (Myo5a-Bmp5) double mu
tants in mouse specific locus mutation experiments has generally been assum
ed to be the result of double nondisjunction such that the mutant inherits
two copies of chromosome 9 carrying the recessive alleles from the test-sto
ck. A homozygous viable Myo5a-Bmp5 double mutant was recovered recently in
our laboratory. We were able to genetically analyse both the Myo5a-Bmp5 reg
ion and proximal and distal markers in the original mutant as well as in of
fspring of the original mutant. Our results indicate the mutational event t
o be due to mitotic recombination and not double non-disjunction.