Growth and the distal tip of mouse chromosome 7

This review concerns the general problem of understanding growth control in the whole organism, starting with a saltatory change in size generated by a chromosome translocation or a mutation in a single gene. In particular, c hanges in insulin-like growth factor-II levels, by genetic and embryologica l manipulation, have major effects on wet weight size, but the intermediary events that link these levels to this measure of growth are uncertain. Thu s it is currently impossible to eliminate any of the intermediary candidate processes that have been observed in model systems, including changed rate s of apoptosis, cell multiplication, protein synthesis, capillary permeabil ity and fluid transport.