Helicobacter pylori infection and age on the development of intestinal metaplasia - A multiple logistic regression analysis

BACKGROUND/AIMS: Both intestinal metaplasia (IM) and Helicobacter pylori (H . pylori) infection have been Linked to gastric carcinogenesis in an age-de pendent manner. However, their relationship remains ill defined, especially with respect to age. METHODOLOGY: Three hundred and two asymptomatic subjects (167 males and 135 females; mean age 44.3+/-11.1 years) underwent complete endoscopic examina tion and biopsy at the antrum and the corpus. H. pylori infection was diagn osed according to histopathology and serology, while IM was determined by h istopathology. RESULTS: Eighty-four patients (27.8%) had IM, while 185 patients (61.3%) we re seropositive to H. pylori. The frequency of IM was higher in patients wi th gastric ulcer (9/14, 64.3%) than in those with minimal change (68/229, 2 9.7%) or duodenal ulcer (7/59, 11.9%), both p<0.01. Patients with IM had a higher mean age (49.5+/-14.1 vs. 42.3+/-9.0, p<0.01) and a higher H. pylori prevalence than those without IM (61/84, 72.6% vs. 124/218, 56.9%, p<0.01) . The concordance rate of H. pylori infection between histopathologic and s erologic diagnosis was lower in patients with IM (67/84, 79.8%) than those without (196/218, 89.9% p<0.05). Using logistic regression analyses, the de velopment of IM was noted to be independently related to both H. pylori inf ection (odds ratio=1.97, 95% confidence interval: 1.1(3.53)) and age (odds ratio=1.93, 95% confidence interval: 1.51(2.47)), CONCLUSIONS: These data suggest that age and H. pylori infection are indepe ndent risk factors for the development of IM. Furthermore, H. pylori infect ion may have been underestimated in patients with IM because of the use of a single method of detection.