We describe a 12 year-old patient that relapsed into fulminant non A, non B
, non C (NANBNC) hepatitis 10 weeks post-clinical recovery. A complete clin
ical and pathological evaluation, including an ultra-structural examination
of a liver biopsy was consistent with the diagnosis of NANBNC hepatitis. T
he patient relapsed into hepatic failure and required transplantation. NANB
NC hepatitis may have a relapsing form that can lead to hepatic failure req
uiring transplantation. Consultants in hepatology should have a high degree
of clinical awareness and maintain prolonged patient follow-up.