The action of vasoconstrictive agents on human tubal arteries

The aim of this investigation was to compare the response of small arteries of the human tuboovarian vasculature to certain vasoactive agents. Ring pr eparations of the arteries were isolated and mounted in tissue chambers for isometric recording of wall tension. The arteries were exposed to the vaso active agents adrenalin, prostaglandin F-2 alpha and two vasopressin analog ues. Adrenalin, prostaglandin F-2 alpha, lysin-vasopressin and triglycyl-ly sine-vasopressin all produced powerful vasoconstriction, the greatest effic acy being shown by and lysine-vasopressin, The maximum response occurred af ter addition of a third compound to a combination of two, irrespective of w hich combination was used. Adrenalin showed faster contraction velocity tha n the other agents. The results indicate that the human tuboovarian arterie s may be constricted by a variety of physiological and pharmacological stim uli, at least partly acting via different effector mechanisms. It is propos ed that these vasoconstrictive agents-alone or in combination-may be useful in conjunction with gynaecological endoscopic surgery, e,g, in tubal pregn ancy or ovarian cysts.