J. Topping et al., Marked variation in antiphospholipid antibodies during pregnancy: relationships to pregnancy outcome, HUM REPR, 14(1), 1999, pp. 224-228
Variations in blood concentrations of antiphospholipid antibodies (APA) wer
e investigated through the course of pregnancy in women who had a history o
f recurrent pregnancy loss, and were related to changes in pregnancy outcom
e. Serial measurements of APA were made in 16 women with antiphospholipid s
yndrome (APS) and 16 with negative APA tests pre-pregnancy. There was consi
derable intraindividual variation in test results through pregnancy. There
was a significantly higher ratio of dilute Russell's viper venom time and I
gG ACA titre in the first trimester compared with results pre-pregnancy in
women with APS. Furthermore, transiently positive APA results were noted in
the control group during pregnancy and some women with antiphospholipid sy
ndrome tested negative for APA in mid- and late pregnancy. We have demonstr
ated clinically important variations in the results of tests for APA during
pregnancy in women with APS.