Marked variation in antiphospholipid antibodies during pregnancy: relationships to pregnancy outcome

Citation
J. Topping et al., Marked variation in antiphospholipid antibodies during pregnancy: relationships to pregnancy outcome, HUM REPR, 14(1), 1999, pp. 224-228
Citations number
31
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
HUMAN REPRODUCTION
ISSN journal
02681161 → ACNP
Volume
14
Issue
1
Year of publication
1999
Pages
224 - 228
Database
ISI
SICI code
0268-1161(199901)14:1<224:MVIAAD>2.0.ZU;2-3
Abstract
Variations in blood concentrations of antiphospholipid antibodies (APA) wer e investigated through the course of pregnancy in women who had a history o f recurrent pregnancy loss, and were related to changes in pregnancy outcom e. Serial measurements of APA were made in 16 women with antiphospholipid s yndrome (APS) and 16 with negative APA tests pre-pregnancy. There was consi derable intraindividual variation in test results through pregnancy. There was a significantly higher ratio of dilute Russell's viper venom time and I gG ACA titre in the first trimester compared with results pre-pregnancy in women with APS. Furthermore, transiently positive APA results were noted in the control group during pregnancy and some women with antiphospholipid sy ndrome tested negative for APA in mid- and late pregnancy. We have demonstr ated clinically important variations in the results of tests for APA during pregnancy in women with APS.