The case of a patient with systemic lupus erythematosus presenting with sev
ere leg cellulitis caused by Hemophilus influenzae non-B biotype III is rep
orted. Skin infections caused by H. influenzae in general, and of the extre
mities in particular, seem to be rare in adults. This is the first reported
case of cellulitis caused by H. influenzae biotype III. The infection was
treated successfully,vith antibiotics. This case highlights the importance
of blood cultures and prompt antimicrobial treatment in febrile adults with
cellulitis, especially immunocompromised patients.