Predictors for the need of blood transfusion were analyzed using multi
ple regression analysis in 1689 patients undergoing elective major abd
ominal surgery before the age of 80 years and with a preoperative bloo
d hemoglobin concentration above 110 g/L. Rectal surgery for malignant
disease and pancreatic surgery (for malignant or benign disease) were
associated with higher transfusion requirements (mean 2.4 units) than
other operations (0.6 units). If two autologous units had been availa
ble in these patients, the fraction needing allogeneic transfusion cou
ld have been reduced from 59% to 31%. It would not be effective to pre
donate more than 2 units. For other types of surgery the rate of allog
eneic transfusion would not have been much reduced, and most autologou
s blood would have been wasted.