Neuropsychological impairment-associated visual field deficits in HIV infection

Purpose. To examine the relationship between loss in peripheral visual sens itivity and neuropsychological functioning in seropositive patients with hu man immunodeficiency virus (HIV) without infectious retinopathy. METHODS. Subjects carefully screened for retinal disease and well-matched a cross demographic and medical variables were grouped according to normal (p erimetry-abnl) versus abnormal (perimetry-abnl) performance on achromatic a utomated perimetry and short-wavelength automated perimetry, standard clini cal ophthalmologic measures of visual function. Ail subjects completed a de tailed neuropsychological test battery and were classified as impaired or u nimpaired, globally and across eight neurocognitive domains. Subjects were also classified according to whether they met diagnostic criteria for minor cognitive/motor disorder (MCMD) or HIV-associated dementia (HAD). RESULTS. Visual field loss was associated with lower performance in the abs traction, perceptual-motor, learning, and motor domains. Significant group differences were also found on numerous individual neuropsychological tests . Based on clinical ratings, we found deficits in learning and motor functi oning. No perimetry-abnl subjects met criteria for MCMD or HAD, whereas 32% of perimetry-abnl subjects met diagnostic criteria for syndromic cognitive disorders (five MCMD and one HAD). In a subset of subjects who underwent a lumbar puncture, there was a trend for the perimetry-abnl group to have a higher concentration of beta(2) microglobulin, a marker for central nervous system immune activation. CONCLUSIONS. These results suggest that in some HIV-infected people reduced visual function may be caused by nonretinal disease, and perimetry may pre sent a sensitive measure of HIV-related brain dysfunction.