Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum

We report the in-vitro susceptibility of 27 clinical isolates of Scedospori um apiospermum and 43 of Scedosporium prolificans. S. apiospermum was resis tant to fluconazole and flucytosine, with variable susceptibility to amphot ericin B, itraconazole, ketoconazole and susceptible to miconazole. Voricon azole was much more active than fluconazole and flucytosine, more active th an amphotericin B, itraconazole and ketoconazole and was as active as micon azole against S. apiospermum isolates. Voriconazole and the other six antif ungal agents showed low activity against S. prolificans isolates.