Various hematopoietic malignant disorders have been shown to bear chromosom
e abnormalities ny different chromosomal regions in a wide variety of eral
laboratories have identified a trithorax-related gene that is involved in r
oost of the 11q23 abnormalities. Although some patterns and associations be
tween the partner genes are beginning to ernerge, it is not yet possible to
frame a single unifying hypothesis for 11q23 leukaemic transformation. The
aim of this review is to summarise the recent data concerning these 11q23
rearrangements and the understanding of their consequences.