A STUDY OF THE LUND-MANCHESTER RESEARCH CRITERIA FOR FRONTOTEMPORAL DEMENTIA - CLINICAL AND SINGLE-PHOTON EMISSION CT CORRELATIONS

We evaluated the Lund-Manchester research criteria (LMRC) for frontote mporal dementia (FTD). With single-photon emission CT, we diagnosed 30 patients with FTD. These patients were compared with 30 with a resear ch diagnosis of Alzheimer's disease (AD). We scored every patient on e ach LMRC item and compared the two groups. A discriminant function sho wed that loss of personal awareness, hyperorality, stereotyped and per severative behavior, progressive reduction of speech, and preserved sp atial orientation differentiated 100% of FTD and AD subjects. Items re lating to affect and physical findings were not different in FTD versu s AD. Loss of personal awareness, eating, perseverative behavior, and reduction of speech are the LMRC items that most clearly differentiate FTD from AD.