Chromosomal abnormalities in renal cell neoplasms associated with acquiredrenal cystic disease. A series studied by comparative genomic hybridization and fluorescence in situ hybridization

Sporadic renal cell carcinomas (RCCs) display different chromosomal abnorma lities according to their morphology; gains of chromosomes 7 and 17 and los s of Y are commonly observed in papillary lesions, whereas loss of 3p seque nces and multiple losses of specific chromosomes are found in non-papillary and chromophobe cell carcinomas, respectively, Acquired renal cystic disea se (ARCD) is associated with an increased incidence of renal cell tumours, especially papillary lesions, The aim of this study was to examine a series of ARCD-related tumours for chromosomal abnormalities and to compare the f indings with those abnormalities commonly observed in sporadic RCCs. Nine t umours from four patients with ARCD were examined using comparative genomic hybridization (CGH) and interphase cytogenetics. Gain of chromosomes 7 and 17 was observed in all four papillary lesions and loss of Y in three. In a ddition, gain of chromosome 16 was observed in three papillary tumours, Thr ee chromophobe RCCs originating from the same kidney showed different genom ic profiles; two had no abnormalities, whereas one showed loss of chromosom e 17p, Two non-papillary RCCs failed to show chromosome 3p alterations, In conclusion, renal cell tumours de, eloping in ARCD may show chromosomal abn ormalities both similar to and different from those seen in sporadic tumour s. Copyright (C) 1999 John Wiley & Sons, Ltd.