Effect of methotrexate on tubal epithelium - A report of three cases

BACKGROUND: Tubal effects of methotrexate injections have been poorly repor ted. CASES: Three fallopian tubes were examined with light microscopy 9-13 month s after tubal methotrexate injection (one case) and intramuscular methotrex ate injection (two cases) given for the treatment of unruptured ectopic pre gnancies. No evidence of tubal damage was found. CONCLUSION: These three cases confirm previous experimental wand clinical d ata showing the absence of a direct adverse effect of methotrexate on the f allopian tubes in the treatment of ectopic pregnancy.