Objective To analyze the long-term nutritional effects of supplemental gast
rostomy feedings in undernourished patients with cystic fibrosis.
Design Longitudinal, retrospective assessment of anthropometric measures be
fore and for up to 4 years after gastrostomy.
Subjects/setting All patients at a large cystic fibrosis care center who un
derwent gastrostomy between 1980 and 1993 when they were at least 1 year ol
d and were followed up for a minimum of 1 year after gastrostomy.
Statistical analyses performed The Mann-Whitney U test was used to compare
anthropometric values measured during 4 postgastrostomy time intervals with
values measured during the year preceding gastrostomy.
Results The 21 patients ranged in age from 1.1 to 20.8 years (median age =
7.4 years). They had mild to moderate malnutrition at the time of gastrosto
my. Patients were followed up for a mean of 39 months after gastrostomy. Su
pplemental feedings were associated with significant improvements in weight
and height percentiles for age, and in weight as a percentage of ideal wei
ght. Improvement in weight occurred earlier than improvement in height. Amo
ng subjects followed up for at least 18 months after gastrostomy, median we
ight percentile for age increased from 2% for the year before gastrostomy t
o 12% for the period 6 to 18 months after gastrostomy (P < .001) and 19% fo
r the period 30 to 48 months after gastrostomy (P = .002 compared with befo
re gastrostomy). Other nutritional parameters followed similar, although le
ss dramatic patterns. Gastrostomy feedings were well tolerated and associat
ed with only minor complications.
Conclusions Long-term gastrostomy feedings appear to be a safe and effectiv
e means of improving nutrition in malnourished patients with cystic fibrosi
s. Clinical dietitians should function as care managers for patients with c
ystic fibrosis who are receiving supplemental gastrostomy feedings.