This paper focuses on psychiatric aspects of portal-systemic encephalopathy
(PSE) due to chronic liver disease and/or portal-systemic shunting. Clinic
al syndromes of PSE are discussed from the point of view of biological psyc
hiatry, but, psychological consequences of concomitant cognitive disorders
are also addressed. Psychiatric symptoms of early PSE and sleep disorders i
n patients with chronic liver disease are of specific interest.