Mobilization of polonium-210 by meso-2,3-dimercaptosuccinic acid mono-N-alkylamides in rats

The effectiveness of three meso-2,3-dimercaptosuccinic acid mono-N-alkylami des - monoisopropylamide (Mi-PDMA), monoisobutylamide (Mi-BDMA) and monoiso amylamide (Mi-BDMA) - on the mobilization of intravenously injected Po-210 nitrate has been studied in female Wistar rats. Only Mi-BDMA proved to be a n effective chelating agent for decreasing Po-210 in the whole of the tissu es investigated. This compound was effective when injected either immediate ly after Po-210 gp I h later (the reduction of total body Po-210 in, treate d rats was 73 and 76 % of the controls, respectively). A substantial reduct ion in the Po-210 content was seen in the spleen (39 and 46 % of controls, respectively), liver (34 and 35 % of controls, respectively) and skeleton ( 32 and 40% of controls, respectively). On the other hand, an increase in th e Po-210 content was found in the muscles (136 and 130 % of controls, respe ctively) and blood (152 and 178 % of controls, respectively). The Po-210 co ntent of the kidneys remained unchanged after the Mi-BDMA treatment. It is concluded that only a small difference in the size of the alkyl chain on th e amide nitrogen in the molecule changes the ability to mobilize polonium.