Metallic interactions in hyperthyreosis: a problem of contributors to pathopoiesis

Metallic interactions in hyperthyreosis (HT) patients have been investigate d in comparison with those in control humans by the use of a systemic analy sis. Significant decreases in the mean concentrations of magnesium, mangane se and chromium in serum have been found in the HT patients having all the HT markets (thyrotrophic hormone -TSH, free thyroxin -T-4 free triiodothyro nine -T-3) typically changed Through a systemic analysis, founded on partia l (rho) and multiple (R) correlations, the metallic and hormone interaction s have been modelled and contrasted with the coincidences traditionally ana lysed on a basis of the mean values and common correlations The interaction s, unlike coincidences, determine mechanisms underlying the observed phenom ena TSH, T-3 and T-4 have been shown to be the only direct causative factor s of HT as indicated by the partial correlations between the binary index o f HT (IH) and these parameters: rho(1H-TSH)=-0.99, delta(1H-TSH)=87.7%, rho (1H-T4)=0.96, delta(1H-T4)=11.9%, rho(1H-T3)=0.73, delta(1H-T3)=0.3%, and b y R1HTSH-T4-T3=0.998 showing completeness of the {IH,TSH,T-3,T-4} system Co nsequently, it has been proven that the changes in the metallic concentrati ons in serum are effects not causes of HT.