Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan

Authors
Nishimura, T Takeda, M Shinosaki, K Nishikawa, T Nakamura, Y Yoshida, Y Sasaki, H Arai, H Hirai, S Shouji, M Isse, K Tanaka, K Hamamoto, M Yamamoto, H Matsubayashi, T Nakashima, K Urakami, K Adachi, Y Nakamura, S Toji, H Yoshida, H
Citation
T. Nishimura et al., Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan, METH FIND E, 20(9), 1998, pp. 793-799
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
ISSN journal
03790355 → ACNP
Volume
20
Issue
9
Year of publication
1998
Pages
793 - 799
Database
ISI
SICI code
0379-0355(199811)20:9<793:BACSOA>2.0.ZU;2-O
Abstract
The fundamental reagent capability and clinical significance of ApoE gene t yping has been investigated. The result of each test shows that the reagent capability satisfied the expected standard. Four-hundred thirty-nine sampl es classified into three groups (Alzheimer's disease (AD), other types of d ementia and nondementia) were measured to examine the clinical significance . The rate of epsilon 4 genotype of each group was 31.5%, 14.6%, 10.4%, res pectively. The AD group had a higher rate than the other groups (p < 0.001) . The measurement of ApoE genotype is suggested to be rueful as one of the guidelines in the diagnosis of AD. (C) 1998 Prous Science. All rights reser ved.