The role of oocyte transcription, the 5 ' UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization

Authors
Saunders, C Cohen, RS
Citation
C. Saunders et Rs. Cohen, The role of oocyte transcription, the 5 ' UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization, MOL CELL, 3(1), 1999, pp. 43-54
Citations number
59
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR CELL
ISSN journal
10972765 → ACNP
Volume
3
Issue
1
Year of publication
1999
Pages
43 - 54
Database
ISI
SICI code
1097-2765(199901)3:1<43:TROOTT>2.0.ZU;2-M
Abstract
The establishment of the major body axes of the Drosophila egg and future e mbryo requires strict regulation of gurken mRNA and protein localization. H ere, we show that grk mRNA and protein localization is dependent on synthes is of grk transcripts in the oocyte nucleus and on RNA localization element s in the 5' portion of the transcript. We also show that gurken mRNA and pr otein localization is dependent on region-specific translation of gurken tr anscripts and identify K10 as a probable negative regulator of gurken trans lation.