Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle

Authors
Sakai, Y Iwamura, Y Hayashi, J Yamamoto, N Ohkoshi, N Nagata, H
Citation
Y. Sakai et al., Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle, MUSCLE NERV, 22(2), 1999, pp. 258-261
Citations number
21
Categorie Soggetti
da verificare
Journal title
MUSCLE & NERVE
ISSN journal
0148639X → ACNP
Volume
22
Issue
2
Year of publication
1999
Pages
258 - 261
Database
ISI
SICI code
0148-639X(199902)22:2<258:AECMDD>2.0.ZU;2-#
Abstract
The present study was conducted to determine the effects of acute overload exercise on mitochondrial DNA and the structure of skeletal muscles. Rats w ere forced to run for 20 min until reaching complete exhaustion. We detecte d the large-scale deletion (7052 bp) of mitochondrial DNA by the nested pol ymerase chain reaction, and also observed mitochondrial ultrastructural cha nges in the soleus muscle. (C) 1999 John Wiley & Sons, Inc.