Steroid-responsive multifocal demyelinating neuropathy with central involvement

We describe 2 patients with associated central and peripheral demyelination . Electrophysiological studies revealed a demyelinating polyneuropathy with sensory and motor conduction blocks. Visual evoked potentials were abnorma l. Motor evoked potentials showed abnormal central conduction time in 1 pat ient. Magnetic resonance imaging revealed regions of abnormal high signal i n the spinal cord and brain; sural nerve biopsy disclosed a demyelinating n europathy. Both patients showed clinical and electrophysiological improveme nt after steroid therapy. (C) 1999 John Wiley & Sons, Inc.