In vivo dominant lethal effect of pyrimethamine in male mouse germ cells

Citation
U. Egeli et al., In vivo dominant lethal effect of pyrimethamine in male mouse germ cells, MUTAGENESIS, 14(1), 1999, pp. 67-69
Citations number
23
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTAGENESIS
ISSN journal
02678357 → ACNP
Volume
14
Issue
1
Year of publication
1999
Pages
67 - 69
Database
ISI
SICI code
0267-8357(199901)14:1<67:IVDLEO>2.0.ZU;2-0
Abstract
Pyrimethamine is used for treatment of malaria and toxoplasmosis. The embry otoxicity and clastogenicity of pyrimethamine is known and our aim was to i nvestigate its dominant lethal effect in vivo. For this purpose, we used th ree groups of Swiss-albino male mice and a control group. We injected males with doses of 16, 32 or 64 mg/kg pyrimethamine and housed them with 10 fem ales/male for each mating interval. Females were sacrificed and their uteri were evaluated for dominant lethality. As a result of this study we found that pyrimethamine induced dominant lethal mutations in the third, fourth a nd sixth weeks at the 64 mg/kg dose level, without the effect being dose-de pendent. We conclude that pyrimethamine is a suspected germ cell mutagen.