Sr. Klapper et al., Unilateral proptosis in an immunocompetent man as the initial clinical manifestation of systemic Hodgkin disease, OPHTHALMOL, 106(2), 1999, pp. 338-341
Objective: Orbital involvement in Hodgkin disease (HD) is rare. Previously
reported cases of HD in patients without the acquired immunodeficiency synd
rome have been diagnosed late in the course of established systemic disease
. The authors describe an immunocompetent man with orbital infiltration as
the initial manifestation of systemic HD,
Design: Case report,
Participants: A 47-year-old man with acute progressive, painless proptosis
of the left eye is described.
Intervention: A well-defined, homogeneous soft tissue mass of the superior
left orbit was evident on computed tomography, and an incisional biopsy of
the nontender mass was performed.
Results: The histopathologic findings were characteristic of HD, Systemic i
nvestigations showed clinical stage 3A HD, Ten months after completion of h
ybrid chemotherapy, the patient remained in complete remission from his HD.
Conclusion: Hodgkin disease presenting initially in the orbit of a patient
with the acquired immunodeficiency syndrome has been described previously.
The patient presented in this report is the first case of HD in the recent
English literature with the initial manifestation in the orbit of an otherw
ise immunocompetent patient.