Combined penetrating keratoplasty and trabeculectomy with mitomycin C

Objective: To evaluate corneal graft survival and intraocular pressure cont rol in eyes that have undergone combined penetrating keratoplasty and trabe culectomy with mitomycin C (MMC). Design: Retrospective noncomparative case series. Intervention: Penetrating keratoplasty combined with trabeculectomy with MM C and other surgical procedures, Participants: Twenty-four eyes of 22 patients undergoing combined penetrati ng keratoplasty and trabeculectomy with mitomycin C, Main Outcome Measures: Corneal graft clarity and intraocular pressure contr ol. Results: The cumulative probability of corneal graft survival was 85% at 1 year and 60% at 2 years, The cumulative probability of adequate pressure co ntrol was 67% at 3 months, 55% at 12 months, and 50% at 24 months. The inci dence of bleb failure was higher in cases involving additional concomitant procedures, such as anterior vitrectomy, lens implantation or exchange, and drainage tube implantation. Conclusions: Combined penetrating keratoplasty and trabeculectomy with mito mycin C is associated with good corneal graft survival but also a risk of e arly failure of intraocular pressure control. Other concomitant procedures during the combined penetrating keratoplasty/trabeculectomy may increase th e risk of early bleb failure.