Liver transplantation for endstage hepatitis C cirrhosis in a patient withprimary hypogammaglobulinaemia

Liver transplantation was performed in a patient with primary hypogammaglob ulinaemia, chronic hepatitis C and hepatic failure. The immediate posttrans plant period was uncomplicated, Owing to a stricture of the choledochojejun ostomy; the patient Has reoperated with construction of a hepaticojejunosto my 11 month posttransplant. The patient remained hepatitis C virus (HCV) RN A-positive, with high and increasing levels of HCV, Liver biopsies demonstr ated the recurrence of HCV. 14 months alter the transplantation the patient developed severe diarrhoea caused by Cryptosporidium parvum. The infection did not respond to available therapeutic measures. He deteriorated with de velopment of liver failure and died 18 months after the transplantation, Th e present case report illustrates the difficulties associated with organ tr ansplantation in patients, with primary hypogammaglobulinaemia.