High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced Nephropathia epidemica

Authors
Kanerva, M Vaheri, A Mustonen, J Partanen, J
Citation
M. Kanerva et al., High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced Nephropathia epidemica, SC J IN DIS, 30(5), 1998, pp. 532-534
Citations number
20
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00365548 → ACNP
Volume
30
Issue
5
Year of publication
1998
Pages
532 - 534
Database
ISI
SICI code
0036-5548(1998)30:5<532:HAOTNF>2.0.ZU;2-K
Abstract
The biallelic polymorphisms in the tumour necrosis factor-alpha (TNF-alpha) gene promoter region were studied in patients with nephropathia epidemica (NE). The rarer TNF2 allele, associated with a high TNF-alpha producer phen otype, was more frequently found in hospitalized NE patients (42%,) than in healthly controls (15%; p = 0.0064). The putative role of TNF2 as an indep endent risk factor for NE is discussed.