Objective: The medical literature suggests that alcoholics may present
greater challenges to achieving clinical pain control than nonalcohol
ics. This study was undertaken to test the hypotheses that: (1) signif
icant differences exist between alcoholics and nonalcoholics on detect
ion and pain thresholds during electric tooth stimulation; (2) group d
ifferences exist in the depth and time course of pulpal anesthesia; an
d (3) responses to tooth stimulation are associated with severity of a
lcoholism and/or other psychological factors. Method: Male alcoholics
(n = 22) in aftercare treatment (mean length of sobriety = 113 days) a
nd age-matched nonalcoholics (n = 22) received 1.0 ml of 3% mepivicain
e at the apex of a maxillary lateral incisor and saline placebo at the
of the contralateral incisor. Results: At baseline no group differenc
es were found on sensory thresholds. During drug intervention signific
ant drug and time effects for both detection threshold (p <.0001) and
pain threshold (p <.0001) were found, but group differences and intera
ctive effects were not significant. By exploratory regression analysis
of alcoholic subjects, history of depression/unhappiness was signific
antly associated with shallower pulpal anesthesia, whereas high need f
or control/low actual control and frequency of treatment for detoxific
ation were associated with deeper anesthesia. Conclusions: Our finding
s suggest alcoholics in recovery are not at increased risk for inadequ
ate pain control with local anesthesia.