Clinical evidence suggests that cellular immunity is involved in controllin
g human immunodeficiency virus-1 (HIV-1) replication. An animal model of ac
quired immune deficiency syndrome (AIDS), the simian immunodeficiency virus
(SIV)-infected rhesus monkey, was used to show that virus replication is n
ot controlled in monkeys depleted of CD8(+) Lymphocytes during primary SIV
infection. Eliminating CD8(+) lymphocytes from monkeys during chronic SIV i
nfection resulted in a rapid and marked increase in viremia that was again
suppressed coincident with the reappearance of SIV-specific CD8(+) T cells.
These results confirm the importance of cell-mediated immunity in controll
ing HIV-1 infection and support the exploration of vaccination approaches f
or preventing infection that will elicit these immune responses.