Smoking during pregnancy and Poland sequence: Results of a population-based registry and a case-control registry

As Poland sequence (PS) could have a vascular disruptive origin, here we an alyzed the possible relationship between maternal smoking during pregnancy and PS, using data from two registries with different methologies: the Hung arian Congenital Abnormality Registry (HCAR), which is a population-based r egistry, and the Spanish Collaborative Study of Congenital Malformations (E CEMC), which is a hospital-based and case-control study. The results presen ted here in a multivariate analysis, although based on a small sample size, suggest that maternal smoking during pregnancy may increase the risk for P S by about 2-fold. This result was similar in the two studied programs with different methodologies and different uncontrolled confounding factors. Ho wever, as this is the first time that PS has been associated with maternal smoking during pregnancy, further analyses are needed to confirm our findin gs. Teratology 59:35-38, 1999. (C) 1999 Wiley-Liss, Inc.